Isoxsuprine

What is isoxsuprine?

Isoxsuprine is a vasodilator that relaxes blood vessel walls outside major organs. It has been used to help treat frostbite in birds and in certain conditions in dogs.

It is used “off label” or “extra label”. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully.

How do I give my pet isoxsuprine?

Isoxsuprine comes in tablet and powder form.

• Tablets and powder are given orally (by mouth). The powder is often used in compounding a liquid oral solution.
• This medication can be given to your pet with or without food. If your pet vomits after getting it on an empty stomach, give it with food or a small treat to see if this helps. If vomiting continues, contact your veterinarian.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears your pet is feeling better.

This medication will take effect quickly, in about 1 to 2 hours. This medication is short-acting, meaning that effects should stop after 24 hours.

What if I miss giving my pet the medication?

Give the missed dose as soon as you remember and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give the pet two doses at once.

Are there any potential side effects from isoxsuprine?

Isoxsuprine may cause the following side effects:

• vomiting and/or diarrhea
• decreased appetite

The following reactions are rare, but if they occur, contact your veterinarian immediately:

• an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
• fainting, collapse

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Are there any risk factors for this medication?

This medication should be AVOIDED in animals who: 

• have known allergies to any components
• have given birth within one week
• have bleeding

Are there any drug interactions I should be aware of?

No known drug interactions have been reported for this medication.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

Your veterinarian may schedule follow-up visits for monitoring to ensure the medication is working. In this case, follow your veterinarian’s directions.

How do I store isoxsuprine?

• Store tablets and powder at room temperature, in the original container. 
• Follow storage and expiration recommendations for specially compounded formulas.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.