Mupirocin Otic

What is mupirocin otic?

Mupirocin otic, also known as pseudomonic acid A, is an antibiotic used in the treatment of ear infections. It may be specially compounded and/or combined into a formulation with other medications.

It is used “off label” or “extra label” to treat ear infections in animals. Many drugs are commonly prescribed for off-label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully.

How do I give my pet mupirocin otic?

Mupirocin otic comes in ointment and liquid suspension forms. 

• Ointments and liquid drops are applied directly to the external ear canal. 
• Before applying the medication, clean the affected area as directed by your veterinarian.
• This medication needs 10 minutes of contact with the affected area for it to be effective. Do not let your pet scratch or groom the ears for at least 30 minutes after applying.
• Wash your hands after application and avoid contact with eyes.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.

What if I miss giving my pet the medication?

Give the missed dose as soon as you remember and then continue with the regular dosing schedule. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not give the pet two doses at once.

Are there any potential side effects from mupirocin otic?

Mupirocin otic may cause the following side effects:

• redness, itching, and/or pain at site of application
• decreased energy level or appetite
• increased thirst or urination
• worsening of the ear infection

The following reactions are rare, but if they occur, contact your veterinarian immediately:

• an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24 hours.

Are there any risk factors for this medication?

This medication should be AVOIDED in animals:

• allergic to any of its components
• allergic to polyethylene glycol

This medication should be used with CAUTION in pets that are pregnant or breeding.

Are there any drug interactions I should be aware of?

No known drug interactions have been reported. 

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

Your veterinarian may schedule a follow-up visit for after the course of medication is complete to ensure the infection has been cleared and/or do additional testing to ensure this is the right medication for the type of infection that is present. In this case, follow your veterinarian’s directions.

How do I store mupirocin otic?

• Store the medication in its original container, protected from light, at room temperature. 
• Keep the cap tightly closed.
• If your veterinarian or pharmacist has made a special (compounded) formulation for your pet, follow the storage recommendations and expiration date for the product.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.