Molidustat

What is molidustat?

Molidustat (brand name Varenzin-CAI) is a medication used to treat anemia (low red blood cell number) in cats with chronic kidney disease. Molidustat helps increase red blood cell production. It is conditionally approved for use in cats only.

How do I give my pet molidustat?

Molidustat comes in liquid suspension form.

• Liquids are given orally (by mouth).
• You can give this medication with or without food. If your pet vomits after getting it on an empty stomach, give with food or a small treat to see if this helps. If vomiting continues, contact your veterinarian.
• Give this medication directly into your cat’s mouth using the provided syringe – do not place it in food.
• Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears your pet is feeling better.

This medication may take several days to start working. This medication is moderate-acting, meaning that effects may last several days.

What if I miss giving my pet the medication?

If you miss a dose, give it as soon as you remember, and then continue with the regular dosing schedule. However, if it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not give the pet two doses at once. 

Are there any potential side effects from molidustat?

Molidustat may cause the following side effects:

• vomiting

The following reactions are rare, but if they occur, contact your veterinarian immediately:

• an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
• changes in gum color
• fast heart rate
• seizures

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Are there any risk factors for this medication?

This medication should NOT BE USED in cats who:

• have known allergies to any component of the medication
• are breeding, pregnant, or nursing

This medication should be USED WITH CAUTION in cats who:

• are less than one year old
• have a known history of seizures
• have a known risk of blood clot formation

Are there any drug interactions I should be aware of?

Certain medications should be USED WITH CAUTION when given with molidustat, including: 

• oral medications containing aluminum, calcium, iron, zinc and/or magnesium
• phosphate binding agents (e.g., lanthanum, sevelamer)
• erythropoiesis stimulating agents (e.g., darbopoetin)

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Red blood cell level (HCT or PCV) will be checked before starting this medication, during treatment, and after stopping this medication. Follow your veterinarian’s recommendation on frequency of testing. 
• Your veterinarian may schedule follow-up visits for monitoring to ensure the medication is working. In this case, follow your veterinarian’s directions.

How do I store molidustat?

• Store at room temperature in original container. 
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.