Fenofibrate
What is fenofibrate?
Fenofibrate is a fibric acid derivative used as an anti-lipemic agent to lower triglycerides (a type of fat or lipid) in dogs. Its use in cats and other animals has not been studied.
It is used off label (extra label) in veterinary medicine. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.
How do I give my pet fenofibrate?
Fenofibrate comes in capsule and tablet forms.
- Both forms are given orally (by mouth).
- Fenofibrate comes in many formulations that may not be bioequivalent – confirm with your veterinarian you are using the appropriate formulation.
- This medication is given with food, usually the first meal of the day.
- Give this medication to your pet for the entire time prescribed by your veterinarian, even if it appears that your pet is feeling better.
This medication should take effect within a few hours, though effects may not be outwardly visible.
What if I miss giving my pet the medication?
Give the missed dose as soon as you remember and then wait the recommended time as prescribed by your veterinarian for the next dose. Do not give the pet two doses at once.
Are there any potential side effects from fenofibrate?
Fenofibrate may cause the following side effects:
- flatulence and/or diarrhea
- loss of appetite, nausea
The following reactions are rare, but if they occur, contact your veterinarian immediately:
- an allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment. Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately.
This medication is short-acting, meaning that effects will last about 24 hours, though effects may last longer in pets with kidney or liver disease.
Are there any risk factors for this medication?
Fenofibrate should NOT BE USED in animals who:
- are allergic to any component of the medication
- have liver disease and/or gallbladder disease
Fenofibrate should be USED WITH CAUTION in pets who:
- have kidney disease, diabetes mellitus, and/or hypothyroidism
- are geriatric
- are nursing
Are there any drug interactions I should be aware of?
Certain medications should be USED WITH CAUTION when given with fenofibrate, including:
- cannabidiol
- cholestyramine
- colchicine
- cyclosporine
- glipizide
- mycophenolate
- omeprazole
- statins (e.g. lovastatin)
- ursodiol
- warfarin
Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.
Is any monitoring needed with this medication?
- Your veterinarian will assess fasted baseline blood work (including cholesterol and triglycerides) before starting this medication.
- Your veterinarian may schedule follow-up visits for monitoring. In this case, follow your veterinarian’s directions.
- At home, monitor for any abnormal changes. If these occur, discontinue the medication and contact your veterinarian.
How do I store fenofibrate?
- Store at room temperature of 25°C (77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F).
- Protect from light and moisture.
- Keep medication out of reach of children and pets.
What should I do in case of emergency?
If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Adverse effects should be reported to the FDA or Health Canada.
© Copyright 2024 LifeLearn Inc. Used and/or modified with permission under license. This content written by LifeLearn Animal Health (LifeLearn Inc.) is licensed to this practice for the personal use of our clients. Any copying, printing or further distribution is prohibited without the express written consent of LifeLearn. This content does not contain all available information for any referenced medications and has not been reviewed by the FDA Center for Veterinary Medicine, or Health Canada Veterinary Drugs Doctorate. This content may help answer commonly asked questions, but is not a substitute for medical advice, or a proper consultation and/or clinical examination of your pet by a veterinarian. Please contact your veterinarian if you have any questions or concerns about your pet’s health.